Transdermal drug delivery systems have been around for decades, and current technologies (e.g., patches, ointments, and creams) enhance the skin permeation of low molecular weight, lipophilic drugs that are efficacious at low doses.The objective of current transdermal drug Oyster delivery research is to discover ways to enhance skin penetration of
The article discusses the origins of Sergei Yesenin’s acquaintance faux flower with the novel What Is to Be Done? by N.G.Chernyshevsky: this happened in Spas-Klepikovskaya second-class teacher’s school in 1909-1912.The work was read among the intellectuals, and students outside of school hours argued about it and embraced the ideals of
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths worldwide due to high recurrence rates after curative treatment and being frequently diagnosed at an advanced stage.Immune-checkpoint inhibition (ICPI) has yielded impressive clinical successes in a variety of solid cancers, however results in treatment of HCC have
Prominent theories suggest that compulsive behaviors, characteristic of obsessive-compulsive disorder and addiction, are driven by shared deficits in goal-directed control, which confers vulnerability for developing rigid habits.However, recent studies have shown that deficient goal-directed control accompanies several disorders, including those wi
Epithelial tissues form folded structures during embryonic development and organogenesis.Whereas substantial efforts have been devoted to identifying mechanical and biochemical mechanisms that induce folding, whether and how their interplay synergistically shapes epithelial folds remains poorly understood.Here we propose a mechano-biochemical model